A5337: Safety and Efficacy of Sirolimus for HIV Reservoir Reduction in Individuals on Suppressive Antiretroviral Therapy
When a person becomes infected with HIV the immune system (the system that helps fight infection) is weakened (partly because the number of CD4 cells goes down). Despite successful treatment with anti-HIV therapy, latent reservoirs (infected cells that are not actively producing HIV) remain in the blood and contribute to a process called immune system activation and inflammation in the body. This may contribute to HIV persisting in cells in the body even while taking medications to treat HIV.
- HIV-infected men and woman, at least 18 years of age
- Taking anti-HIV medications that have controlled the HIV viral load (“undetectable” levels) for 2 or more years.
- Protease inhibitors and cobicistat are not allowed on this study.
- CD4 cell count greater than or equal to 400 cells/mm3
- No active hepatitis B or C infection, tuberculosis, or shingles
- No vaccinations in the past 14 days.