NWCS 408: Examining Longitudinal Cytokine Profiles in HIV-TB Co-infected Participants Examining Longitudinal Cytokine Profiles in HIV-TB Co-infected Participants to Study the Exit from Latent TB Infection and Death: A Supplemental Proposal for A5274

Study Location:

India

Topic:

Tuberculosis and HIV

IRB#:

IRB00091167

Enrollment:

Open

Trial Period:

Ongoing

Using existing data from A5274 and data obtained from retrospectively testing available biospecimens, we propose the following specific aims:

Specific Aims:

  1. To determine whether the levels of a panel of proinflammatory cytokines and IL-32 at baseline are associated with progression to TB disease in advanced HIV-infected persons
  2. To determine whether baseline levels of cytokines associated with IL-1 and type 1 interferons are associated with early mortality  
  3. To examine the association between longitudinal levels of the cytokines examined in aims 1 and 2  and development of TB or early mortality on ART 

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