Symptom screening among HIV-infected pregnant women is acceptable and has high negative predictive v high negative predictive value for active tuberculosis

Topic:

HIV Prevention

Authors:

Gupta A, Chandrasekhar A, Gupte N, Patil S, Bhosale R, Sambarey P, Ghorpade S, Nayak U, Garda L, Sastry J, Bharadwaj R, Bollinger RC; Byramjee Jeejeebhoy Medical College–Johns Hopkins University Study Group

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We evaluated tuberculosis (TB) screening among 799 human immunodeficiency virus (HIV)-infected pregnant women in India. Eleven (1.4%) had active TB. The negative predictive value of screening using cough, fever, night sweats, or weight loss was 99.3%. Tuberculin skin test and targeted chest radiography provided no substantial benefit. TB symptom screening, as recommended by the World Health Organization, is effective for ruling out TB in HIV-infected pregnant women.

Clin Infect Dis. 2011 Nov;53(10):1015-8. doi:10.1093/cid/cir605. Epub 2011 Sep 21. PubMed PMID: 21940417; PubMed Central PMCID: PMC3193828

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