. . . At the press conference, Chaisson said that while prevention of TB with isoniazid is effective, "uptake has been appallingly bad." He added that the longer the course of the therapy is, the more people stop taking it, and described "a sense of futility" among clinicians about this problem.

A shorter, 4-week course of rifapentine and isoniazid had shown promise in animal studies, the authors said, so they hypothesized it would be non-inferior to the usual 9-month standard of care. "The bottom line is," Chaisson added, "it was." . . . 

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