Ned Sacktor, MD

CRS:

JHU

Role:

Investigators

Position:

Site Investigator

Email:

sacktor@jhmi.edu

For the past 16 years my research studies have focused on the epidemiology, clinical characterization, and treatment of HIV-associated neurocognitive disorders (HAND). With respect to epidemiology, as a co-investigator in the Multicenter AIDS Cohort Study (MACS), we described changes in the incidence of HIV-associated neurological disease after the introduction of highly active antiretroviral therapy (HAART), and have examined the effect of age on longitudinal neuropsychological test performance.  In collaboration with Dr. Victor Valcour and Dr. Cecilia Shikuma at the University of Hawaii, we established a cohort specifically designed to examine the effect of aging on HIV-associated cognitive impairment. In the NorthEast AIDS Dementia (NEAD) cohort we validated the International HIV Dementia scale which is now used throughout the world to quickly identify individuals at high risk for HIV dementia. In collaboration with Makerere University, we performed a comprehensive study of the clinical characterization of HIV dementia in Uganda. My research has also evaluated the utility of surrogate markers for HIV Dementia including neuroimaging markers and markers of oxidative stress. With respect to therapy, I have been principal investigator  of both small pilot studies (selegiline) and larger studies [AIDS Clinical Trials Group (ACTG) 5235 study (minocycline study)], to examine the efficacy of potential adjunctive therapies for the treatment of HIV dementia. We are currently examining the safety, tolerability and efficacy of both fluconazole and paroxetine for the treatment of HAND.

  • Member, Neurology Collaborative Science Group (Dec 2015)
  • Protocol Chair, ACTG 5235
  • Sacktor, N., McDermott, M.P., Marder, K., Schifitto, G., Selnes, O.A., McArthur, J.C., Stern, Y., Albert, S., Palumbo,D.,Kieburtz, K., Marcaida, J., Cohen, B., Epstein, L. HIV associated cognitive impairment before and after the  advent of combination therapy. J NeuroVirology 2002;8:136-142.
  • Sacktor, N., Haughey, N., Cutler, R., Tamara, A., Turchan, J., Pardo, C., Vargas, D., Nath, A. Novel markers of oxidative stress in actively progressive HIV dementia. J Neuroimmunol 2004;157:176-184.
  • Sacktor, N., Wong, M., Nakasujja,  N., Skolasky, R., Selnes, O., Musisi, S., Robertson, K., McArthur, J., Ronald, A., Katabira, E. The International HIV Dementia Scale: a new rapid screening test for HIV dementia. AIDS 2005 19;1367-1374.
  • Sacktor, N., Skolasky, R., Selnes, O., Watters, M., Poff, P., Shiramizu, B., Shikuma, C., Valcour, V. Neuropsychological test profile differences between young and old HIV+ individuals. J Neurovirology 2007;13:203-209.
  • Sacktor, N, Nakasujja, N., Robertson, K., Clifford, D. HIV-associated cognitive impairment in Sub-Saharan Africa: the potential impact of clade diversity. Nature Clinical Practice Neurology 2007 Aug;3(8) 436-443.
  • Sacktor, N, Nakasujja, N., Skolasky, R., Robertson, K., Musisi, S., Ronald, A., Katabira, E., Clifford, D. B. Benefits and risks of stavudine therapy for HIV associated neurological complications in Uganda. Neurology 2009;72:165-170. PMCID:PMC 2677497
  • Sacktor, N., Nakasujja, N., Skolasky, R., Rezapour, M., Robertson, K., Musisi, S., Katabira, E., Ronald, A., Clifford, D., Laeyendecker, O., Quinn, T. HIV subtype D is associated with dementia compared to subtype A in immunosuppressed individuals at risk for cognitive impairment in Kampala, Uganda. Clin Inf Dis 2009;49:780-786. PMCID:PMC2941149
  • Sacktor, N., Skolasky, R.L., Cox, C., Selnes, O., Becker, J.T., Cohen, B., Martin, E., Miller, E., for the Multicenter AIDS Cohort Study (MACS). Longitudinal psychomotor speed performance in HIV+ individuals: impact of age and serostatus. J NeuroVirology 2010; 335-341. PMCID:PMC3068912
  • Sacktor, N., Miyahara, S., Deng, L., Evans, S., Schifitto, G., Cohen, B.A., Paul, R., Robertson, K., Jarocki, B., Scarsi, K., Coombs, R.W., Zink, M.C., Nath, A., Smith, E., Ellis, R.J., Singer, E., Weihe, J., McCarthy, S., Hosey, L., Clifford, D.B., and the ACTG 5235 team.
    Minocycline treatment for HIV-associated cognitive impairment: results from a randomized trial. Neurology 2011;77:1135-1142. PMCID:PMC3174065
  • Sacktor, N., Nakasujja, N., Okonkwo, O., Skolasky, R., Robertson, K., Musisi, S., Katabira,
    E. Longitudinal neuropsychological test performance among HIV seropositive indoviduals in Uganda. J NeuroVirology 2013 (1) 48-56. PMCID: PMC3568232

Categories

Leadership Committees
CRS
Roles

Clinical Trials

NWCS 445: Novel Biomarkers to Shorten TB Treatment

Objectives: Primary: To develop a highly predictive algorithm that identifies TB patients who will be cured by treatment...

Read More

HPTN 078: Enhancing Recruitment, Linkage to Care and...

The purpose of this study is to develop and assess the efficacy of an integrated strategy that includes feasible and scalable...

Read More

A5346: Sitagliptin for Reducing Inflammation and Immune...

The purpose of the study is to evaluate whether sitagliptin (Januvia is the brand name for sitagliptin)...

Read More

A5329: Interferon –Free Therapy for Chronic Hepatitis C...

A5329 is a study for people who are infected with both HIV and the Hepatitis C virus (HCV) and have never taken Hepatitis C...

Read More

A5350: Effects of Visbiome Extra Strength on Gut Microbiome...

Many factors contribute to the development of aging-related conditions, including gastrointestinal (GI) diseases, such as...

Read More